Tempus xE whole exome DNA sequencing

Overview

xE is a whole exome 19,000+ gene panel by DNA seq that provides potentially actionable and biologically relevant alterations, TMB, as well as potential germline findings.

How to order

Ordering flexibility

 

Tempus offers a variety of options to customize molecular profiling for patients.

  • xE and xR may be ordered as a standalone test or in combination

  • Streamlined ordering process through Tempus Hub, paper requisition, or directly from your EHR

Access Tempus Hub ↗︎
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Resources

White paper sheet with a grey clip attached at the top.Requisition Form
A close-up view of a federal register notice form with various fields.

xE Requisition Form

Three white rectangles stacked vertically with soft grey shadows, forming layers.Specimen Guideline
Tempus document titled "Specimen Guidelines for Providers" for medical professionals.

Specimen Guidelines

Three white rectangles stacked vertically with soft grey shadows, forming layers.Specimen Guideline
Digital interface showing the Tempus Sequencing Laboratories web page with test information.

Lab Overview

Learn more

Clinical Trials →
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Financial assistance

We help provide access to our tests for all patients in financial need

 

Approval of the financial assistance application is based on your household income and takes into account all life circumstances. Once a financial assistance application is submitted either online or over the phone, you will receive a decision at the time of submission.

Apply for financial assistance online at access.tempus.com ↗︎

  • If approved, you will know immediately about the maximum out of pocket cost of your testing.

  • Please contact billing@tempus.com if you are concerned about out-of-pocket costs and would like to discuss your options.

All U.S.-based patients are eligible to apply for financial assistance regardless of insurance status. For international patients, we offer a self-pay option. If you have any questions, please email patients@tempus.com. Authorization for Medical Records: Through access.tempus.com, applicants are directed to our Notice and Authorization for Medical Records authorization form. This optional form allows us to request outcomes and other medical records from your health care providers. Please see the form for more information.

Test design

xE Performance Specifications

Variant ClassLimit of DetectionSensitivitySpecificity
Single Nucleotide Variants (SNVs)
10.0% VAF
99.4%
99.9%
Insertions and Deletions
10.0% VAF
97.1%
99.9%
Copy Number Gains
30.0% Tumor Purity
85.7%
N/A
The analysis of xE paired normal match includes potential germline findings that may be reported in a limited set of 110 genes (including both hereditary cancer and non-cancer related genes) and may or may not be related to the patient’s current cancer diagnosis.*

 

Potential germline gene selection for reporting was based on ACMG recommendations1, NCCN GuidelinesⓇ2, and other published literature.

References

  1. Miller DT, Rehm HL, Bale SJ, et al. ACMG SF v3.0 list for reporting of secondary findings in clinical exome and genome sequencing: a policy statement of the American College of Medical Genetics and Genomics (ACMG). Genet Med. 2021;23(8):1381-1390.
  2. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®). ©National Comprehensive Cancer Network, Inc. 2023. All rights reserved. Accessed [6.2.23].

 

* Normal match sequencing is utilized to ensure fidelity of somatic variant calling. Tempus xE is not a validated germline panel, and Potential germline findings should not be used as a diagnostic determination for hereditary cancer risk.

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