Genomic and transcriptomic differences between early-onset and non-early-onset PDAC

Genomic alterations play a pivotal role in distinguishing early-onset from older PDAC cohorts

INDICATION
Pancreatic
BIOMARKER
KRAS
BRCA2
SMAD4
CDKN2A

Diverging bar chart shows genetic mutation frequencies across BOPC and nBOPC pancreatic cancer groups.

 

Frequency of genetic alterations in key genes comparing EOPC and nEOPC cohorts. Bar lengths represent the percentage of cases harboring each alteration (Gene - Pathogenicity - Somatic/Germline), with the number of cases (n) indicated. Statistical significance is denoted by asterisks (* p<0.05, ** p<0.01, *** p<0.001).