Validating FFPE-based genomic profiling in pancreatic cancer
Commercial NGS panel on routine samples matches TCGA findings and finds actionable targets
Incidence of commonly mutated genes amongst the cohort and TCGA database
The most commonly mutated genes include KRAS (Baylor 88.1% vs. TCGA 90.7%) and TP53 (Baylor 77.9% vs. TCGA 69.3%). KRAS VAF ranged from 1.7%-42.2%. TP53 VAF ranged from 2.1%-57.4%. CDKN2A VAF ranged from 5.1%-36.2%, and 5/22 CDKN2A alterations were copy number losses. SMAD4 VAF ranged from 4.1%-33.2%, and 4/14 SMAD4 alterations were copy number losses.
Lens Library
