LAG3 expression as a predictive biomarker for 1L ICI in melanoma

RWD analysis shows LAG3 expression predicts outcomes of different ICI regimens in melanoma

INDICATION
Melanoma
BIOMARKER
LAG3

rwOS following monotherapy vs combination therapy in patients with LAG3-L and LAG3-H tumors

 

 

CoxPH analysis found a significant interaction between LAG3 and 1L ICIs on rwOS (p=0.02), suggesting the ICI effect on rwOS differs between LAG3-L and LAG3-H (p=0.02). In the LAG3-L group, patients treated with aPD1 had reduced rwOS compared to the aCTLA4/PD1 cohort (HR, 1.88, p=0.03), while in the LAG3-H group patients treated with aPD1 had numerically higher rwOS compared to the aCTLA4/PD1 cohort (HR, 0.67, p=0.2).

 

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