Transcriptional and immune signatures of ESR1 and PIK3CA co-mutations in HR+ MBC

Discovery of distinct immunosuppressive microenvironments to guide combination therapies

INDICATION
Breast
BIOMARKER
ESR1

Differential Gene Expression in PIK3CA-Mutant vs. WT HR+/HER2- Metastatic Breast Cancer

 

 

Volcano plot illustrating upregulated and downregulated genes in PIK3CA-mutant tumors compared to wild-type. Key genes with significant expression changes are highlighted.

 

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