Transcriptomic profiles of treatment resistance in 1L mCRC

Uncovering gene expression changes and potential resistance mechanisms to BRAFi in CRC

INDICATION
Colorectal
BIOMARKER
BRAF

 

Volcano plot with differential gene expression results comparing pre- and post-treated biopsies from patients with CRC, treated with chemotherapy alone in 1L (by Wilcoxon rank-sum test). Highlighted genes are related to PI3K pathway*. Dots in orange represent genes enriched in post-treated samples, and blue-colored dots represent enrichment in pre-treated samples.

 

*curated canonical GSEA set

 

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