Uncovering resistance mechanisms in ADC-treated urothelial cancer with multimodal RWD

Identifying genomic and transcriptomic markers of ADC response in UC patients

INDICATION
Urothelial

 

Differential gene expression analysis comparing responder (R; n=25) vs. non-responder (NR; n=32) cohorts within UC patients that received EV+pembrolizumab in 1L. Biopsies were collected prior to treatment initiation. Colors according to gene fold-change and significance: significant is defined as p <0.05, enriched and unenriched are defined as fold change ≥ 1 and ≤ -1, respectively.

 

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