Impact of pre- and post-treatment ctDNA positivity on outcomes in NSCLC

Real-world ctDNA levels provide significant prognostic value before and after therapy

INDICATION
Lung
BIOMARKER
ctDNA

(A) Pre-1L
Kaplan-Meier curve illustrates lower survival with detectable ctDNA (2.1 months) versus undetected (6.82 months).

 

(B) 14-90 days post-1L
Kaplan-Meier curve shows ctDNA detected patients have lower median survival.
Kaplan-Meier survival curves comparing rwPFS for ctDNA >= 1% vs ctDNA < 1 % in pre- (A) and post- 1L treatment (B) biopsies from patients with NSCLC. Shaded areas represent the 95% confidence intervals. Median survival times (months) are specified. Log-Rank test P value is indicated.