RB1 loss-of-function mutations in post-Osimertinib NSCLC and prognostic implications

Post-Osimertinib RB1 loss-of-function mutations are associated with worse prognosis in NSCLC

INDICATION
Lung
BIOMARKER
RB1

A) Kaplan-Meier curve comparing overall survival probability for RB_LOF and WT groups over 60 months.
B)
Forest plot shows overall survival hazard ratios for RB1 and TP53 genetic alterations.

 

Figure 1. A) Real-world overall survival, anchored on biopsy date, for patients with a post-Osimertinib biopsy prior to intervening therapy. Kaplan-Meier curve stratified on presence of RB1 loss of function. B) Cox regression model including both RB1 and TP53 loss of function.