Tracking PPM1D post-treatment prevalence to evaluate prognosis in lung adenocarcinoma

Liquid biopsy tracking reveals PPM1D mutations as an emerging biomarker for poor survival

INDICATION
Lung
BIOMARKER
PPM1D

A) Bar chart showing PPM1D mutation prevalence in 1L LUAD by time to xF sample.

 

B)
Kaplan-Meier survival curve comparing mutant and wild-type groups, with mutant showing lower survival (p=0.0479).

 

Figure 1: A) PPM1D prevalence in xF samples relative to non-EGFR targeted 1L therapy in Lung Adenocarcinoma. Samples are not patient matched. B) Real-world overall survival from time of xF sample based on presence of PPM1D mutation.