Predicting outcomes in NSCLC with combined CD8 and PD-L1 biomarkers
Improved OS following ICI treatment is associated with high CD8T and PD-L1 in mNSCLC
rwOS in patients treated with 1L ICI ± CT in PDL1 subgroups stratified by CD8 status
After 1L ICI ± CT, CD8T(High vs. Low) further stratified OS within PD-L1 groups (<1%, 1-49%, and ≥50%). HRs were adjusted for age at treatment start, sex, driver mutation status, treatment category, TMB category, and smoking status.
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