Researchers from Tempus partnered with Washington University School of Medicine to study the association between germline alterations in cancer-predisposition genes across lung cancer patients.  

Historically, the understanding of the molecular features of lung cancer has been derived primarily from a limited approach focussed on analysis of biopsies from smokers. Few studies have identified the underlying genetic alterations linked to ancestry, smoking status, and tumor characterization. This project aims to gain a broad understanding of these germline features and how they are linked to tumor location and presentation.

This study was presented at the ASCO Annual Meeting in June 2023.