What sequencing analysis is performed?
Somatic sequencing uses formalin-fixed paraffin embedded (FFPE) or fresh-frozen specimens to identify genomic alterations in cancers. To sequence circulating hematologic malignancies, Tempus Labs accepts bone marrow or peripheral blood in an EDTA tube. In addition, FFPE bone marrow clots and FFPE tissue specimens involved with hematological malignancies are accepted as well. All raw sequencing data is available, and potentially relevant therapies are reported and prioritized based on the strength of the clinical evidence that establishes the association between a given genomic alteration and a relevant therapeutic option. RNA sequencing on tumor samples may be performed to analyze actionable genomic aberrations (e.g., gene fusions and/or rearrangements), gene expression analysis, rare and novel transcript discovery, and splice variant detection.*
*RNA sequencing is clinically and analytically validated for unbiased detection of oncogenic fusions and/or rearrangements. RNA Sequencing is considered research use only for xTv4 NYS.