Publications

Abstract Recent rapid progress in the field of computational pathology has been enabled by foundation models. These models are beginning to move beyond encoding image patches toward whole-slide understanding, but their clinical utility remains limited. Here we present PRISM2, a multimodal slide-leve … Continued

Abstract Purpose – The vast majority of reported ALK rearrangements occur at exons 17-20. ALK-rearrangements occurring earlier in the ALK gene (eALK) are poorly characterized and rarely reported, potentially because most clinically available biomarker testing is optimized for detecting common ALK re … Continued

Abstract The Coalition to Advance Real-World Evidence through Randomized Controlled Trial Emulation (CARE) Initiative seeks to advance understanding of when real-world data (RWD) can generate valid treatment effectiveness estimates by emulating completed oncology randomized controlled trials (RCTs). … Continued

Abstract Prospective evidence on clinical utility of AI in histopathology is limited. We conducted a prospective study across three National Health Service specialist centres in England to evaluate a commercially available AI system for assistance in prostate biopsy reporting. Of 1613 cases, 1049 we … Continued

Abstract Epidermal growth factor receptor (EGFR) is an oncogenic driver in multiple cancers and a therapeutic target of tyrosine kinase inhibitors and neutralizing monoclonal antibodies. However, resistance to EGFR-targeted therapies, particularly the anti-EGFR antibody cetuximab, remains a clinical … Continued

Background … Continued

Background CHK2 is a DNA damage response (DDR) protein critical for maintaining genomic stability. Germline CHEK2 variants occur at 1-2% in the general population and confer elevated risk for multiple cancers. Loss-of-function mutations in DDR genes can sensitize tumors to immunotherapy through effects on tumor immunogenicity and immune signaling. We examined the relationship between germline … Continued

Background PIN1 is a phosphorylation-dependent prolyl isomerase that regulates oncogenic pathways, including cancer stemness, epithelial–mesenchymal transition, immune modulation, and cholesterol biosynthesis. While mechanistic studies implicate PIN1 in aggressiveness across cancer types, its clinical relevance in UC remains unclear. Methods The Tempus Lens platform was used to identify a real-world cohort of patients (pts) with UC … Continued

Background Patients with breast cancer frequently experience anxiety and depression, yet systemic delays in psychiatric care often leave oncologists to manage these conditions. The recent adoption of DPYD genotyping into NCCN guidelines for fluoropyrimidine safety marks a shift toward routine pharmacogenomic (PGx) integrations in oncology. This creates an opportunity to expand PGx to supportive care, … Continued

Background Current National Comprehensive Cancer Network (NCCN) guidelines for germline testing in neuroendocrine neoplasms (NENs) rely on organ-specific, syndrome-driven algorithms that may not adequately capture hereditary risk. We sought to analyze prevalence of P/LP germline variants in epithelial NENs and investigate relevant associations. Methods Germline genetic testing results were analyzed from 3,611 probands. Cohort 1 … Continued