Researchers from Tempus partnered with City of Hope to study the differences in tumor microenvironment and mutational landscape of primary and metastatic colorectal cancer sites.

This study utilized the whole transcriptome expression data of liver metastasis and lung metastasis in microsatellite stable colorectal cancer. The results uncovered a significant finding: a more favorable immune profile was found in lung metastasis compared to liver metastasis. This discovery has the potential to revolutionize the approach to treating colorectal cancer cases with metastasis, as it suggests that the site of metastasis could be taken into account when tailoring treatment approaches.

This study was presented at the ASCO Gastrointestinal Cancers Symposium in January 2023.