Receive report status and quick access to patient information /// EXPLORE NOW Tempus One: New AI Clinical Assistant Available for All Providers


Do you have advanced cancer with a PALB2 mutation?

Connect with our Tempus Nurse Navigators to learn more about PAVO, a Tempus study of niraparib in certain advanced cancer patients with PALB2 mutations.

Talk to a Nurse Navigator

Study Overview

View the full study here: NCT05169437

Official title

A Single-Arm Phase-II Study of Niraparib in Locally Advanced or Metastatic Solid Tumor Patients With PALB2 Mutations




18+ years old; male & female.

Medical condition

Advanced stage or metastatic or stage III or stage IV solid tumor with a PALB2 mutation or PALB2 germline mutation.

Solid tumor cancers include: Anal, Appendiceal, Bladder, Breast, Brain, Cervical, Colon, Colorectal, Rectal Endometrial, Uterine, Esophageal, Gallbladder, Biliary Tract Cholangiocarcinoma, Gastro-esophageal, Gastrointestinal stromal tumor (GIST), Head and Neck, Stomach, Small Intestine, Kidney, Lip & Oral, Liver, Melanoma, Mesothelioma, Non-Small Cell Lung, Nonmelanoma Skin, Pancreatic, Sarcoma Small Cell Lung, and Thyroid.

How do I know if I have a PALB2 mutation?

During your cancer evaluation, your doctor may send a sample of your tumor for DNA testing. This can help with choosing a treatment or clinical trial study. If your lab results show a PALB2 mutation, you may be able to join the PAVO study.


Phase 2


Niraparib, in a pill format as an oral drug.


The PAVO study is open and enrolling at nearly 2 dozen locations across the U.S., with more sites opening every month. If you are eligible for PAVO and there is no clinical trial site open near you, we may be able to work with your doctor to quickly open the PAVO study at a treatment center that is close to your location.

GlaxoSmithKline provides drug and funding for this study.

What to expect

  • Connect with a Tempus Nurse Navigator. Fill out the form below. A Tempus Nurse Navigator will contact you within 1 business day to talk to you about the PAVO study.
  • Consult with your doctor. We will share information about PAVO for you to discuss with your doctor. Our Nurse Navigators can also speak with you and your doctor.
  • Enroll in the PAVO trial. Tempus will work with you if you and your doctor determine you are eligible and you want to enroll into the study.
image description
image description image description

Get started

Submit your information and our Tempus Nurse Navigator will connect with you to discuss trials in the TIME program. Or, call us directly at 312.239.6766 9am-5pm CT, Monday-Friday.