Tempus Gene Library

This gene overview is brought to you as part of Tempus’ goal to inform providers about our genomic testing panels and the genes included in our offerings. Through our robust de-identified database of clinical information coupled with molecular testing results, we are capable of providing unique insights into these gene alterations. Many of the gene alterations reported on our somatic and germline panels are often key inclusion criteria for clinical trials.

RAD51B Gene

RAD51 Paralog B

The RAD51B gene is a member of the RAD51 family that functions in the homologous recombination repair (HRR) pathway. Loss of function mutations, copy number loss, and underexpression of RAD51B are associated with cancer progression.

RAD51B alterations in 10 most common cancers – Tempus database

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The above graph is representative of the 3.8M+ de-identified patient records in the Tempus database as of September 30, 2021.

FDA approved drugs for RAD51B mutated cancers

TherapyTumor type (indication)Biomarker
LYNPARZA® olaparib Prostate cancerHRR genes including RAD51B
As of September 30, 2021. HRR – homologous recombination repair; RR – response rate; mPFS – median PFS; mOS – median Overall Survival in months.

Some strategies in clinical trials for patients with RAD51B mutated cancers

MechanismPhase 2Phase 3
PARP inhibitors rucaparib olaparib talazoparib niraparib
ATR Kinase InhibitorVX-970 (M6620)

View a more comprehensive list of clinical trials for patients with RAD51B mutated cancers. The Tempus TIME Trial® Program brings the right clinical trials to the right patients, in days instead of months. Learn how you can enroll today

Additional resources for RAD51B gene:

Additional resources on variants:

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