Early Introductions and Transmission of SARS-CoV-2 Variant B.1.1.7 in the United States

Cell Manuscript
Authors Tara Alpert, Anderson F.Brito, Erica Lasek-Nesselquist, Jessica Rothman, Andrew L. Valesano, Matthew J. MacKay, Mary E. Petrone, Mallery I. Breban, Anne E. Watkins, Chantal B.F. Vogels, Chaney C. Kalinich, Simon Dellicour, Alexis Russell, John P. Kelly, Matthew Shudt, Jonathan Plitnick, Erasmus Schneider, William J. Fitzsimmons, Gaurav Khullar, Jessica Metti, Joel T. Dudley, Megan Nash, Nike Beaubier, Jianhui Wang, Chen Liu, Pei Hui, Anthony Muyombwe, Randy Downing, Jafar Razeq, Stephen M. Bart, Ardath Grills, Stephanie M. Morrison, Steven Murphy, Caleb Neal, Eva Laszlo, Hanna Rennert, Melissa Cushing, Lars Westblade, Priya Velu, Arryn Craney, Lin Cong, David R. Peaper, Marie L. Landry, Peter W. Cook, Joseph R. Fauver, Christopher E. Mason, Adam S. Lauring, Kirsten St. George, Duncan R. MacCannell, and Nathan D. Grubaugh

The emergence and spread of SARS-CoV-2 lineage B.1.1.7, first detected in the United Kingdom, has become a global public health concern because of its increased transmissibility. Over 2,500 COVID-19 cases associated with this variant have been detected in the United States (US) since December 2020, but the extent of establishment is relatively unknown. Using travel, genomic, and diagnostic data, we highlight that the primary ports of entry for B.1.1.7 in the US were in New York, California, and Florida. Furthermore, we found evidence for many independent B.1.1.7 establishments starting in early December 2020, followed by interstate spread by the end of the month. Finally, we project that B.1.1.7 will be the dominant lineage in many states by mid- to late March. Thus, genomic surveillance for B.1.1.7 and other variants urgently needs to be enhanced to better inform the public health response.