Ongoing Partial Response at 6 Months to Olaparib for Metastatic Melanoma With Somatic PALB2 Mutation After Failure of Immunotherapy: A Case Report

A 75-year-old man presented with progressive aphasia. Past medical history included two resected primary cutaneous melanomas of shoulder and forearm, transient ischaemic attacks, non-insulin-dependent diabetes, hypertension, and radical prostatectomy at age 67 years. Family history revealed bowel cancer in the father and ovarian cancer in the daughter, diagnosed at age mid-80s and mid-40s, respectively…